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On MR imaging, areas of fatty sparing may be identified due to the lack of decrease in signal intensity on opposed-phase gradient-echo T1-weighted images and appear hyperintense relative to surrounding steatosis.
However, there is a significant impact on the absolute capacity (Vmax) for these processes following PCN exposure, due to the lack of decrease in concentration of activated PXR following PCN exposure in the stubborn PXR models.
The lack of decrease in u-AQP2 by tolvaptan could be explained by a counteracting effect of increased plasma vasopressin.
The lack of decrease in the third phase slope indicates that this opening was relatively uniform in the lung periphery.
The lack of decrease in u-AQP2 by tolvaptan could be explained by a counteracting effect of a three-fold increase in plasma vasopressin.
The lack of decrease of HMGB1 in serum and tissue after immunosuppressive therapy in the current study may reflect persistent inflammatory activity.
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Therefore, increased diagnostic effort did not explain the lack of decreasing reporting rates.
In a Phase 2 study, all patients receiving doses of 25 mg or higher exhibited a decrease in PTH level following cinacalcet treatment; hence, lack of a decrease might represent treatment non-adherence [ 12].
One possible explanation for the lack of a decrease is the low MPD in these subjects at baseline (mean 12.6%), which may limit further decreases in MPD.
This lack of apparent decrease after MMS treatment probably reflects the great stability of most mature pol III transcripts.
However, the low mortality rate of adult kakapo [18] suggests that the lack of TL decrease with age is not a result of selective mortality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com