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The lack of de novo purine biosynthesis in the malaria parasite Plasmodium falciparum makes the purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) a drug target.
These two problems are: lack of de facto intrinsic quality of service and the problem that relates to end-to-end integrity of the signaling and bearer path for VoIP.
This was aggravated by a lack of de facto independence of stakeholders (Busuioc et al. [2011]; Makhashvili and Stephenson [2013]), who are part of a network of actors in which contributions and thus responsibility are shared.
EWAT differed from the two other examined adipose tissues by its lack of de novo lipogenesis control in response to HFD.
A more striking metabolic feature of SFBs is the almost complete lack of de novo biosynthesis pathways for amino acids, vitamins/cofactors and nucleotides (Table 2).
Lack of de novo histone synthesis causes a string-dependent cell cycle arrest in G2 phase, suggesting a novel chromatin assembly checkpoint monitoring chromatin integrity.
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Protozoan parasites cannot synthesize purine bases (DNA/RNA) which is essential for survival as lack of de-novo pathway.
Lack of de-novo extra-cellular matrix (ECM) milieu, which plays a crucial role in generating physical and chemical signals besides providing structural support is attributed to be the major hurdle in normal cell growth in vitro.
The accumulation of stranded passengers grew on Friday at Roissy-Charles de Gaulle Airport, the major hub for Paris, where a lack of de-icing fluid compounded the delays as planes sat on the tarmac.
This difficulty is compounded when the sample frame is inaccurate due to a lack of de-registration or notifications of change of residence, which affects contact rates (and might potentially introduce biases in the final sample).
This discrepancy points to both a culture of impunity and a lack of de-escalation training among US law enforcement.
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CEO of Professional Science Editing for Scientists @ prosciediting.com