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And so the lack of DC representation on the All-Star team is reflective of their consistency as a team unit.
Mechanisms that control downregulation of adaptive immunity in mother and fetus include local immunosuppression, lack of DC migration to local lymph nodes, and presence of intrauterine Tregs during pregnancy [24, 25].
I'm scared of Hillary, but Sarah's strong in a different way, her lack of DC experience is a real positive, her being governor is a big plus, she knows how to juggle well.
The striking differences observed is explained by the lack of DC which produce cytokines [16] as well as by the lack of DC which will activate down-stream effector cells such as NK cells and CD8+ T-cells [17], [18].
Indeed, in these patients, the lack of DC was associated with a strongly reduced numbers of circulating Treg.
Studies have shown a lack of DC activation following exposure to UV-inactivated RSV [31], [33], [34], [37], [39].
Similar(52)
It has been shown that the inability to confine viral infections in patients with GATA-2 deficiency correlates well with the extent of cytopenias, namely with the lack of DC-, NK- and CD4pos T-cells.
To circumvent the problem of the lack of DC-SCRIPT in cell lines for functional studies, DC-SCRIPT was cloned in front of the Tet-responsive promoter construct that becomes activated upon addition of doxycycline [MCF7 Tet-on advanced cell line (Clontech)].
The lack of DCs may impair recognition of viruses and intracellular pathogens contributing to disseminated herpes virus infection and mycobacterial susceptibility.
Lack of DCs was highlighted in the description of DCML deficiency (Bigley et al, 2011) but was also previously recorded in at least one case report (Witzke et al, 2004).
In this study, we show that the high frequency of precursor DCs in 16 FD ITD+ AML samples (Lin−/HLA-DR+/CD11c+/CD123+) was associated with a lack of terminal DCs (myeloid DCs: BDCA-1+ or BDCA-3+; plasmacytoid DC: BDCA-2+).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com