Sentence examples for lack of complement from inspiring English sources

The lack of complement is strongly linked with development of autoimmune phenomena.

Mouse ficolin-B is probably unusual in its lack of complement function, because other ficolins for which sequences have been determined contain archetypal MASP-binding sites [ 21].

This work also provides an explanation for the lack of complement activity of mouse ficolin-B: a glutamate residue in place of the usual aliphatic/hydrophobic residue in the residual MASP-binding site.

To explain the lack of complement involvement, we hypothesize that, after MOG-IgG binding, MOG might not aggregate (because of its low abundance) or MOG might become internalized (thus prohibiting C1q activation).

Moreover, muscle biopsies indicate loss of AChR (Shiraishi et al., 2005) and complement deposition (M. Motomura, personal communication) similar to that of AChR-MG, and contrasting with the normal AChR numbers and lack of complement deposition in MuSK-MG (Shiraishi et al., 2005).

This is most likely due to the increased quantity of available C1s in the bead assay, as well as greater antigen density and lack of complement inhibitory receptors on the surface of beads compared to cells, all requiring larger quantities of TNT003 to block complement activation.

The disorder may result from intoxication with bacterial shiga toxin or from complement activation due to lack of complement-inactivating factor H [ 198].

The lack of activated complement components as well as a clear increase in local C3 mRNA expression levels may illustrate the intestines response aimed at protection and preservation.

In this study we were only alerted to potential confounding effects by the lack of increased complement resistance conferred by the common IGR changes found in MenB isolates.

The importance of risk polymorphisms in the development of aHUS is increasingly being recognized, and a lack of identified complement mutations is observed in 25 30% of patients [ 3, 17].

A lack of a full complement of miRNAs has imposed limitations on recognizing their important roles in cancer, including breast cancer.