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Analysis of the iCT versus control CT and iWT animals suggests that this may be due to a lack of AMP production; there was no expression of PPCP in the iCT frogs.
A possible explanation for the lack of AMP hypersensitivity may be that none of the tested AMPs are expressed naturally in C. elegans since e.g. the worm lysozymes are quite different from the chicken-type lysozyme tested here [49].
The lack of AMP gene induction in SIGMAV-infected flies [29] and the lack of a protective effect in DXV-infected flies overexpressing single AMPs [56] suggest that the AMP response is not important for the immune response against viruses in Drosophila.
However, the lack of AMP detectability could either indicate instability or amounts below the detection limit, both valuable reasons to exclude the plant lines from further studies.
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Further analyses are warranted to determine whether this lack of 11q13 amp also contributes to the improved prognosis observed in patients with HPV-positive HNSCC.
One possible explanation for the lack of 11q13 amp in HPV-positive tumours may be that amplification of chromosomal band 11q13 might be unnecessary, as the resulting interaction of the HPV E7 oncoprotein with pRb might allow the cells to be less dependent on CCND1 for cell cycle progression.
However, some flaws hamper the clinical usage of AMPs, such as toxicity to normal mammalian cells and the lack of a cost-effective way of commercial-scale production (Cao et al. 2015).
Of special interest might be the fact that Paneth cells seem to be particularly affected by a lack of nutrition and show reduced AMP expression and granule abberations in a starvation mouse model (Hodin et al, 2011).
Because of the lack of altered microbiota or AMPs in the IEC-KO mice, we more closely examined whether (and which) gut cells might express LepRb.
Perhaps this lack of precedent-setting is why AMP, which is a coalition of the Musicians' Union, the Music Managers' Forum and the Featured Artists Coalition, has decided to bring the issue to EU legislators once and for all.
In response to a lack of nutrients, p53 becomes activated through the activation of AMP-activated protein kinase (AMPK) and the inhibition of AKT.
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