There was a lack of activity, of fresh air.
This finding is in accordance with the proposed lack of activity of Ere(A) in azithromycin37.
However, all the above designs only early terminate a trial due to lack of activity of the study drug.
These structural adaptations seem to favour recognition of large branched substrates and may explain the lack of activity of GH39wh2 toward small xylose-based and other typical substrates from GH39 members, emphasizing the molecular diversity within the GH39 family.
Biophysical studies of carefully designed mutants allowed disentangling dimerization and processing, and we could demonstrate lack of activity of monomeric uncleaved procaspase-8 and of a processed but dimerization-incompetent mutant.
Despite some initial research that reported a lack of activity of trans geometry, complexes with general formula trans-[PtCl2(L)(L′)] exhibit an important cytotoxic activity in cisplatin-sensitive and resistant cell lines.
This contrasts the lack of activity of even shorter N-truncated ETV1 produced by fusion transcripts.
These effects are very specific as evidenced by the lack of activity of some GA analogues that we generated.
Covarrubias and coworkers demonstrate that depletion of a zinc ion, which is coordinated with aspartic acid side chain, leads to the lack of activity of Rv1284 gene [40].
Our data suggest that smoking is associated with plasmalogen-deficiency disorders, caused by reduced or lack of activity of the peroxisomal enzyme alkyl-DHAP.
Because both tagged and untagged Dim2/Pno1 and Rio2 function in other pulldowns, we can rule out lack of activity of these proteins, but not Tsr1.
