Sentence examples for lack of activating from inspiring English sources

Some of the genes found inappropriately methylated are involved in the p53 pathway suggesting that despite the lack of activating mutations of TP53 in ALL, there is an abnormal function of p53 mediated by epigenetic mechanisms.

In addition, due to the lack of activating groups, the labeled compounds usually show a much higher metabolic stability when compared to the activated aromatic compounds.

It seems reasonable to hypothesize that, when this sampling module encounters the appropriate chromatin environment, possibly created by a lack of activating transcription factors, accumulation of PRCs can occur and transcriptional repression can be achieved.

Additional findings from our laboratory also point to the lack of activating mutations in EGFR and ErbB3 genes, giving further strength to ligand-driven tumour cell proliferation as a paramount tumourigenic mechanism within the PDAC microenvironment (Tzeng et al, 2007a).

Therefore, these data suggest that the lack of activating mutations of the eight genes is compatible with a detectable efficient MMR status involving hMLH1 and hMSH2 proteins and imply the presence of alternative pathogenetic mechanisms operating in this type of mucosal melanomas.

Indeed, the lack of activating signals may allow tumors to escape the IS and induce tolerance to the over-expressed tumor Ags [ 43].

It is unclear at this time whether ICP0 directly affects the loss of activated forms of IRF3 or whether activated IRF3 is relatively short-lived and the loss of nuclear IRF3 reflects the lack of newly activated molecules translocating into the nucleus.

In addition, lack of DMoe activates the Rho1-Rok-myosin cascade and JNK-mediated apoptosis in imaginal discs (Warner et al., 2010; Neisch et al., 2010).

Further, we provide evidence that lack of Sirt4 activates a retrograde signaling response from the mitochondria to the nucleus that includes AMPK, PGC1α, key regulators of β-oxidation such as Acetyl-CoA carboxylase, and components of the mitochondrial respiratory machinery.

Of note, there was no growth reduction observed in Z86-treated normal colonic epithelial cell line CCD-841-CoN cells, which are lack of aberrantly activated endogenous canonical Wnt signaling, indicating the selective growth inhibitory effect between cancer cells and normal cells was attributed to the inhibition of Wnt/ β-catenin signaling.

Because of a lack of cardiac activity activated clotting times (ACT) were attempted to be maintained at >200 seconds.