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First, the lack of activated carboxyl groups (i.e., PEG linker AuNVs) results in the deficiency to form polymerization points.
The lack of activated complement components as well as a clear increase in local C3 mRNA expression levels may illustrate the intestines response aimed at protection and preservation.
Notably, our previous findings of a primary impairment of apoptotic events and survival defects in HIBM cells, as shown by the lack of activated Akt response to apoptotic stimuli [18], are in line with the mild mitochondrial alterations described here.
The authors speculate that the lack of activated macrophages' phagocytic function in those Gc2 carriers may increase the risk for implantation of endometriosis tissue in the peritoneal cavity.
However, the work reported a lack of activated MAPK or Akt signaling; thus, the molecular and cellular bases of these defects still largely remain unknown.
The lower expression of these enzymes in the Hpa-tg mouse brain thus correlates with a relative lack of activated macrophages and astrocytes.
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Some of the genes found inappropriately methylated are involved in the p53 pathway suggesting that despite the lack of activating mutations of TP53 in ALL, there is an abnormal function of p53 mediated by epigenetic mechanisms.
In addition, due to the lack of activating groups, the labeled compounds usually show a much higher metabolic stability when compared to the activated aromatic compounds.
It seems reasonable to hypothesize that, when this sampling module encounters the appropriate chromatin environment, possibly created by a lack of activating transcription factors, accumulation of PRCs can occur and transcriptional repression can be achieved.
Additional findings from our laboratory also point to the lack of activating mutations in EGFR and ErbB3 genes, giving further strength to ligand-driven tumour cell proliferation as a paramount tumourigenic mechanism within the PDAC microenvironment (Tzeng et al, 2007a).
Therefore, these data suggest that the lack of activating mutations of the eight genes is compatible with a detectable efficient MMR status involving hMLH1 and hMSH2 proteins and imply the presence of alternative pathogenetic mechanisms operating in this type of mucosal melanomas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com