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In particular, histological analyses revealed the lack of abnormalities in liver, oesophagus and kidney of treated mice.
It may also explain both low morning cortisol in patients with CFS and the lack of abnormalities of hormones of the HPG axis in this study.
In the remaining patient, airway FDG accumulation was evident despite the absence of airway symptoms and a lack of abnormalities in the respiratory function test or CT.
The lungs are particularly susceptible to arsenic in early life, as evident by the lack of abnormalities seen in mice exposed to arsenic in adulthood only.
However, this was not the case in Bug22 mutants, as we have never observed defects in spindle assembly or chromosome segregation (data not shown) consistent with the lack of abnormalities at the onion stage (Fig. 3C).
The restricted expression of sclerostin in the skeleton and the lack of abnormalities in organs other than the skeleton in patients and animals with sclerostin deficiency made this protein an attractive target for the development of a new bone-forming therapy for the management of osteoporosis.
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Rothrock et al. [16] discussed why delayed arteriography would miss a transient spasm/stenosis to confirm migrainous stroke, to justify the lack of abnormality found in angiograms of patients who developed stroke during a migraine attack.
Lack of abnormality on the bone uptake phase of the study favours a benign or mature bone process.
Based on McKusick's classification, the longevity, size, lack of cardiac insufficiency in association with mild cardiac murmurs, lack of abnormality of sella turcica, and the absence of umbilical or inguinal hernia, marked hepatosplenomegaly, and marked corneal opacities warranted the diagnosis of the mild B variant of MPS VI [ 15].
Chromosomal aberrations, such as 13q and 17p deletions detected by standard karyotyping, or t(4 14), t(14 16) and deletion of 17p detected by fluorescence in situ hybridization, were considered as high-risk cytogenetic abnormalities (CA), while a lack of these abnormalities was considered to indicate standard risk.
The lack of major abnormalities is attributed to a marked elevation in the expression of matrix metalloproteinases, for example, MMP2 and MMP14 in the Hpse-KO liver and kidney.
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