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For most carcinogenic and mutagenic effects mechanistic considerations reveal a lack of a threshold, and therefore, the derived minimal-effect level (DMEL) shall be derived.
"One of the biggest problems in every single power the Bill gives and sometimes creates is the lack of a reasonable suspicion — lack of a threshold that is absolutely clear for surveillance powers to be authorised for the purpose of preventing and detecting crime.
The absolute amount of CFTR mediating this effect may be critical to this regulation because the inflammatory markers decreased in a dose-dependent manner with increasing wt-CFTR transfection suggesting that the lack of a threshold level of CFTR is itself an important pro-inflammatory signal.
Again, the lack of a threshold value for acidosis limits the clinical applicability of these findings.
We call upon fellow researchers to breathe new life into the debate on the current methodological challenges associated with measuring IPV, especially the problem of comparing different measurement periods and the lack of a threshold for psychological abuse.
Similar(55)
The origination points of saccades were similarly inconsistent, apparently suggesting a lack of any threshold for triggering that is associated with positional errors.
While another peer who tried unsuccessfully to amend the bill, Green MP Jenny Jones, flagged a lack of requirement of "reasonable suspicion" for powers to be used — and therefore a lack of a clear threshold for authorizing state surveillance — arguing this allows sweeping justification for the usage of the bill's highly intrusive powers.
The 1045+ mutant displayed both reduction and lack of a clear threshold effect for NCE, with respect to EGFR-WT.
Because of the lack of a consensus threshold for defining an abnormal systolic blood pressure (SBP) response, this was analyzed as a continuous variable.
28, 20 Others describe the lack of a clear threshold event, such as a diagnosis, to prompt discussions leaving them to rely on physical or social cues.
However, lack of a discriminatory threshold did not permit this marker to be used to triage patients according to short-term mortality risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com