Sentence examples for lack checkpoints from inspiring English sources

Thus, pre-MBT embryos lack checkpoints that halt the cell cycle in response to DNA damage [30], [32] and are unable to trigger cell death.

Mutants lacking checkpoint function would lose viability.

Bub1 itself (Fig 1K) as well as Bub3 and Mad3 (Supplementary Fig S1I) still localized to kinetochores, but Mad1 and Mad2 were strongly reduced (Fig 1J and K, Supplementary Fig S1I) and cells lacked checkpoint activity (Fig 1L).

"I never thought to ask whether the lead banker owned shares in the other company," Victor I. Lewkow, a longtime lawyer and partner at Cleary Gottlieb Steen & Hamilton, acknowledged to a packed room matter-of-factly last Thursday, demonstrating the utter lack of checkpoints put in place during a typical merger negotiation by an often seven-figure legal team.

Allgame contributor Colin Williamson noted the game as extremely hard due to its "pixel-perfect jumps", the "sheer number of attackers and flying bullets", and a lack of checkpoints within each stage.

rad3Δ cells lack all checkpoint functions.

Immortalization of human prostate cells by c-myc stabilizes telomere length through up-regulation of TERT expression and lack Rb/p16INK4a checkpoint, being easily transformed [36].

Cancer cells that lack this checkpoint would be vulnerable to drugs that increase Geminin activity.

We noted that the lack of checkpoint bypass in the absence of Rad53 is in contrast to the bypass observed in Dbf4 truncation mutants.

Tumour cells frequently lack proper checkpoint function, which leads to aberrant mitosis, transmission of mutated genes, fractured chromatin and eventually cell death.

Likewise, the normal attachment of the chromosomes to the metaphase plate and lack of checkpoint activation that monitors spindle tension [ 65] in geminin-silenced cells suggest that kinetochores are also unaffected by geminin silencing.