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Moreover, extraction of this compound from the intact plant generally requires labour intensive procedures, besides posing environmental concerns.
The major limiting factor in implementing in vitro cell-based therapies is now the lengthy time and cost of such labour intensive procedures.
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However, it is a lengthy and labour intensive procedure.
Apart from this rather exhaustive, financially and labour intensive procedure, more refined functional studies can be undertaken.
Thus, coupling an intelligent biological-activity guided screening with an early efficient dereplication approach avoid spending time in labour intensive procedure of purification and structural elucidation of already known metabolites.
A third factor was the continuous development of medical technology, such as new equipment and labour-intensive procedures.
These recruitment procedures may not be cost feasible on a larger scale; however, less-personalised and labour-intensive procedures may yield lower rates of consent and/or PROMs completion.
However, assessing the stromal contribution is non-trivial given the RNA instability and labour-intensive procedure of segregating stromal from cancer cells (Park et al, 2011).
For example, the isolation of clonal cell lines or transgenic animals showing stable, high level expression of transgenes is usually a slow and labour-intensive procedure because most integration events lead to silencing.
Unfortunately, POMDPs usually require a very labour intensive, manual procedure for their definition and construction.
Frequency of mutations observed in sputum smear-negative samples are also reported in Table 2. Conventional methods for mycobacteriological culture and DST are slow and labour intensive, requiring sequential procedures for isolation of mycobacteria from clinical specimens, identification of MTB complex, and in vitro testing of strain susceptibility to anti-TB drugs.
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