Sentence examples for laborious without from inspiring English sources

Identification of a suitable counterselection marker is complex and often organism specific (11); however, it is often assumed that isolating mutants using two-step allele exchange is extremely laborious without a counterselection marker due to the low frequency at which the second recombination event occurs (11).

The problem is that he does so in a plodding, laborious fashion, without much wit or humor, and without providing any new insights into his subject.

I count myself a fan, but this is an awful moment for Zweig lovers: a clunkingly laborious movie, without any of the style of Max Ophüls's famous Zweig adaptation Letter From an Unknown Woman.

The writing by Christopher Markus and Stephen Mc Feely is laborious and without wit and punch.

In addition, we have achieved simple pathogenic microorganism detection without a laborious sample preparation process and without the use of centrifuges.

But even this written record couldn't be analyzed objectively without laborious processing and analysis.

Codices could be flipped through or opened to any point in the text without laborious unrolling.

In the remainder of the movie, Gilbert often falls into a kind of tragic gloom, a dull, dark seriousness of the eyebrows and forehead; he is laborious and earnest without suggesting anything in particular.

But it can be hard to add up the money for one doctor from several sources, identify the biggest recipients or list them all for a hospital or a city, without laborious work by a computer expert.

This allows generation of large numbers of specific T cells, without laborious selection and expansion procedures.

The double-joint polymerase chain reaction (DJ-PCR) is a technique that can be used to construct vectors for targeted genome integration without laborious subcloning steps.