However, from the green chemistry point of view, such nonaqueous synthesis routes are not ideal and to make AuNPs biocompatible, lengthy, and laborious process of surface functionalization is generally required [21].
This is made possible by the simple "mix-and-read" protocol without laborious sample preparations like surface immobilization or labeling.
Whereas established synthesis protocols that allow for breaking the symmetry of colloid surfaces are laborious and expensive, here we use Janus particles that are based on the ubiquitous layered silicate kaolinite.
This capability aspect of this work is of particular interest since enamel and soft tissue (e.g. buccal) mucosa surfaces require laborious sourcing, as well as raise considerable ethical considerations with studies in vivo.
Back at the lab it's a laborious process getting under the surface, into the little-known center of biodiversity within the reef structure.
However, for conventional bulk solid substrates, such as glass slides [4], polymer monoliths [5, 6], and silica beads [3], the control on their morphologies and functionalizing their surfaces are usually laborious.
In addition, a quicker and less laborious statistical method, known as response surface methodology, was used to investigate and optimize some crucial factors that affected the adsorption.
Field measurement of soil surface roughness is time-consuming, laborious, costly, and, for vegetated areas, impractical.
This resulted in longer application time, as the poultice has to be applied in smaller portions and its adherence to the stone surface was more difficult and laborious.
Better carriers are now being sought to reduce the laborious and time-consuming modification of carrier surfaces, to eliminate errors that arise during weighing of the silica gel, and to eliminate adsorption of contaminants by the surface [ 11– 13].
