Sentence examples for laborious strategy from inspiring English sources

Targeting DCs in vivo via specific surface receptors represents a more direct and less laborious strategy.

An effective but more laborious strategy to rule out unintended effects is to use several independently transformed lines.

First of all, it is a slow, laborious strategy not easily scaled up for rapid generation of tandem repeats with engineered changes.

2, 35 As only some of the less frequent SNPs are statistically associated with height, and in view of the high density of SNPs, our study may be hampered by selection bias 36 and would ideally have required a wider sampling of some 2 000 individuals; however, this was a highly laborious strategy when the complete sequencing technique is applied.

Although newer, and arguably less laborious, strategies to target genes [24] or to tag proteins utilizing novel recombineering strategies [25] are now becoming available, it is important to note that our reporter does represents the first faithful reporter of ADGF-A expression to be published.

Most expression profiling of miRNAs in normal human tissues has been explored in a rather small collection of tissues or miRNAs, in which some of them were restricted by time-consuming and laborious strategies such as Northern blotting or cloning [ 13].

Though laborious, this strategy has major advantages including stable expression of physiological levels of cytokines and localization to the right organ(s).

Despite the drawbacks (unwanted mutations and being time consuming and laborious), this strategy was successful and widely used for rapidly increasing the production yield of antibiotic-producing microbes.

In contrast to the conventional, laborious, shuttle vector strategy described above, the yeast-templated PCR and direct amplicon sequencing approach developed for these studies yields robust sequencing results in roughly 1 day.

Conventional experimental identification of S-nitrosylation sites with a site-directed mutagenesis strategy is laborious and of low-throughput [7], [8].

One of the advantages in our strategy, avoiding laborious initial cloning steps in gene-targeting vector construction, has been achieved also with recombineering, i.e. the use of homologous recombination in E. coli [5].