Well aware of the laborious routes to (especially chiral) triphos ligand derivatives, we sought to improve these preliminary efforts by investigating the viability of P2P surrogates (bidentate + monodentate ligands).
8 Although such methods are usually effective, they require access to highly substituted indole precursors that typically require an overall laborious synthetic route.
Isolated by geology behind the rugged Canadian Shield and many hundreds of miles of wilderness, settlers and their neighbours had access to outside markets and sources of supply only by two laborious water routes.
Bethune ordered Continental's lawyers to begin the laborious process of negotiating route authority to Latin destinations.
Hopstop's route was the most laborious, but also the most adventurous.
(Interview, Manager, Time 2) An interesting example given in this context was that users in outpatients would book appointments on the system using a route that was less laborious, but which meant that, although these appointments would show on their screens as booked, they would not show on the rest of the system as booked.
As with a number of other peer-to-peer lending platforms, LendInvest has worked out algorithms that can bypass some of the more laborious and expensive processes of established routes, with the promise of faster financing and an alternative way for investors to try to make more from the money that they have.
Leave most compounds in their natural state, place some culture bound rituals around them, don't package and distribute them, avoid laborious processes to permit consumption through routes other than swallowing and most of all give purification/distillation a wide berth and many of the most troublesome drugs of the 21st century would be less problematic.
