The process of putting together All the Way… A Decade of Song was laborious for all involved, from balancing the number of hits and new songs to ensuring that each of the latest tracks showed a new side of Dion.
Genome-wide significant linkage was usually required before traditional Sanger sequencing commenced, but without any obvious candidate genes this could then lead to the laborious sequencing of all genes (50 100, depending on the size and location of the linkage region) in the region, potentially taking years before a causal variant and gene were found.
Glyco-Peakfinder (http://www.glyco-peakfinder.org; Maass et al. 2007) is a web-based software tool for semi-automatic de novo composition analysis of glycans, providing computer assistance in the analysis of fragmentation patterns and the laborious manual annotation of all kinds of carbohydrate MS spectra.
The last session of the second round of the talks was "as laborious as all the meetings we have had, but we agreed on an agenda for the next round when it does take place," Brahimi added.
Maybe going out doesn't have to be expensive and laborious after all?
To circumvent the laborious and cost-intensive duplication of all processes during clone generation and quality control, we developed a cloning strategy that allows for the simultaneous generation of two variants of Gateway entry clones, one containing a particular ORF with and the other without the stop codon.
However, most of the time the original raw data is unavailable, and furthermore a complete reanalysis of all data is needlessly laborious.
Even though the Hart and Risley study had encompassed just a few dozen families, the transcribing and coding of all those tapes had been laborious.
First of all, it is a slow, laborious strategy not easily scaled up for rapid generation of tandem repeats with engineered changes.
It was the laborious follow-up to the most profitable entertainment product of all time; Grand Theft Auto V, which grossed a cool $6 billion dollars.
Unfortunately, this is a laborious process and the complexity of the mutational landscape makes impossible to assess the impact of all reported alterations.
