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In particular, they tend to use laborious finger counting procedures when other children have already switching to verbal counting, decomposition and, later, memory retrieval procedures.
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In addition, target-driven selection procedures for new finger combinations typically are laborious and uncertain of success (Thibodeau-Beganny and Joung 2007; Maeder et al. 2009).
Laborious and complex, the talks have been dogged by finger-pointing between rich and poor countries over sharing the burden for curbing carbon emissions.
Stripping removes the loose, dead coat; it may be done by hand, called finger stripping, or plucking, or with a stripping knife; either way, it is a laborious process.
Engineering the mutant allele is laborious, and purification for in vitro studies is problematic because the two critical cysteine residues on each zinc finger quickly oxidize and lose binding activity.
Despite recent success of gene targeting mediated by zinc-finger nuclease (ZFN) [ 4], we chose not to pursue this strategy because of the laborious design process and the toxicity resulted from the "off-target" effects [ 37].
Zinc finger nucleases were expensive and required complex algorithms to design, while TALENs were cost effective but somewhat laborious to generate.
Not laborious.
It was pretty laborious.
It was laborious.
That can be laborious".
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