In the first instance (eighties and early nineties) peptide identification was done by means of laborious extraction procedures in combination with numerous bioassays and purification steps (for review see [ 7]).
The point of this laborious procedure is that this combination of multiplication and division produces a pure, dimensionless number.
Practically, this method is laborious to test every possible combination of test variables as it results in large number of experiments [ 21, 22].
In addition, target-driven selection procedures for new finger combinations typically are laborious and uncertain of success (Thibodeau-Beganny and Joung 2007; Maeder et al. 2009).
However, the large number of even the 'reasonable' mutations and the astronomical number of their combinations renders these laborious studies rather challenging.
Appropriate switching is a laborious task that must carefully consider combination products, routes of administration, and also therapeutic equivalents and their (often differing) doses, if the same active ingredient is not available.
In addition, its application can optimize the laborious process of experimentally screening drug combinations.
To stabilize a protein formulation different classes of excipients are used in combination after carefully selecting through laborious and time consuming trial and error experiments.
Identification of effective LMWGs for food applications usually involves extensive, laborious, and time consuming screening of gelator/solvent combinations.
Hence, the aforementioned laborious techniques seem to be justified and a combination of the Baermann funnel and the Koga agar plate method may lead to the most accurate results.
