With a site launched in 2001, around the time of my own pubescence, the alt pinup Suicide Girls can claim responsibility for quite a few of my erections over the years, so earning one more didn't seem like it'd be too laborious a challenge for them.
Finding clothes that are the right fit can be a laborious, psychologically challenging experience.
Additionally, an olefin present in the linker prevented the use of thioglycosides and the final deprotection of the oligosaccharide after assembly was still laborious and challenging.
On the other hand, NGS approaches are time-consuming, laborious and technically challenging.
The characterization of cyclotides in mixtures using MALDI-TOF/TOF analytics may overcome laborious isolation and challenges in de novo peptide sequencing.
However, the large number of even the 'reasonable' mutations and the astronomical number of their combinations renders these laborious studies rather challenging.
But these three-yearly campaigns – nets are expected to be effective for no more than three years – were, he said, "laborious, difficult and a huge challenge".
Always a mathematical challenge and very laborious.
However, accurate characterization of grain size and shape remains a big challenge due to laborious, time consuming techniques and complex nature of wheat grain shape.
Redesigning a challenge can be laborious as it might imply obtaining data for a new gold standard and change assumptions that simplified the underlying biology and favored a good challenge formulation.
