Sentence examples for laborious and difficult from inspiring English sources

Furthermore, it is very laborious and difficult to find the cause of such nuisance tripping in RCCBs.

It may be a laborious and difficult task to design one controller that fits all operating conditions.

Thus, screening of direct substrates for specific kinases is still laborious and difficult.

The size of the mapped regions of these 17 diseases varies between 0.6 and 7.75 megabases (figure 1) and renders mutational screens for disease association laborious and difficult.

Finally, in Phase 3, the role of Gordon Sweet's Silver staining was determined for the assessment of a third set of cases, to see if this laborious and difficult staining procedure is even necessary.

Even though evaluation of community-based health interventions involving a comparison city as a control region can be laborious and difficult, such approaches are necessary to garner future support from policy-makers and other key stakeholders.

Nevertheless, full automation and hence application in routine laboratories is still hampered by laborious and difficult-to-automate sample pre-treatment protocols.

Metabolic engineering combined with systems biology has contributed to the enhanced production of chemicals and materials by redistributing and optimizing metabolic fluxes (Lee et al. 2011); however, this approach is often extremely laborious, costly, and difficult (Hodgman and Jewett 2012; Kwok 2010).

Randomized trials are often seen as a slow, laborious, expensive, and difficult step in the translational process and are associated with a high attrition rate for drugs.

Obviously, this is a laborious method and difficult to apply to the whole country as it is an exceptionally hard task to evaluate all hospital records for AFP cases, especially since Iraq does not currently have reliable systems for retrospective patient data review [ 13, 19, 21].

It is however laborious and extremely difficult to manually define reliable markers for all possible sub-cellular structures.