Sentence examples for laboratory mutation from inspiring English sources

First, the laboratory mutation sets are expected to contain an overabundance of changes to alanine because of alanine scanning, which is a cost-efficient alternative to testing every possible non-native amino acid (Bromberg and Rost, 2008).

Estimates of the deleterious mutation rate (U SDM ) in C. elegans have been calculated from observable phenotypic declines in fitness in laboratory mutation accumulation lines [ 82- 84] as well as from the direct detection of sequence changes in some of the same mutation accumulation lines [ 85, 86].

Freakishly large, eerily pale and an utter blank on the palate, they could have been ill-advised laboratory mutations: Frankenmussels.

If we assume that mutations that occur in less than 10% of the total cells in the tumor are undetectable in the laboratory, mutations that occur after the fourth cell cycle will be undetectable.

Experiments like these would have been impossible with strong laboratory mutations.

The latter criterion was rendered decisive when it was understood that the non-clumping phenotypes of the C. elegans reference strain N2 was acquired through laboratory mutations [ 49].

The availability of information on over 10 000 laboratory-induced mutations provides an opportunity to (1) measure the performance of computational tools for accuracy in diagnosing laboratory mutations and (2) compare them with the performance observed for a large collection of naturally occurring human variants with and without disease implications.

Ten of these papers used constructs of independently evolved laboratory mutations, while the remaining three papers used combinations of alleles which had evolved in clinical environments which were then transferred onto isogenic backgrounds for further analysis.

We tested and rejected the possibilities that the preponderance of changes to alanine and the presence of multiple base-pair mutations in the laboratory were the reasons for the observed discordance between the performance of computational tools for natural and laboratory mutations.

A total of 1027 formalin-fixed paraffin-embedded (FFPE) neoplastic specimens with a diagnosis of lung cancer, colorectal cancer or melanoma were submitted to a Clinical Laboratory Improvement Amendments (CLIA -certified laboratory for mutation deteCLIA -certifiedGS plaboratorytween April 2013 and September 2014.

In the laboratory, this mutation was found to simultaneously decrease the activity of the respiratory complex as measured by the rate of cytochrome c oxidation and to increase the rate of mitochondrial reactive oxygen generation.