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Furthermore, any laboratory dependent criteria should use assays that are both, widely available and affordable everywhere.
Protocol could include use of use of urine dip-stick and UPCR together to validate more convenient urine dip-stick over the complicated and laboratory dependent UPCR.
4 However, the specific cutoff value is laboratory dependent, and thus screen positive and screen negative results are specified on reports.
Although many instruments have been developed for assessing RBC aggregation using photometric methods, the technical requirements of each apparatus (i.e., the temperature of measurement, disaggregation protocol or sample's oxygenation status) render the results laboratory dependent [ 1].
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However, the dot blotting procedure is laboratory-dependent and time-consuming which needs long result turn-around time (approximately 6 h) [20,21].
Once a substantial percentage of ILI presentations are caused by the pandemic strain, identification of cases for treatment on syndromic grounds alone results in a greater potential impact than a laboratory-dependent strategy.
However, once a substantial percentage of ILI presentations are caused by the pandemic strain, identification of cases (and contacts) to be treated on syndromic grounds alone results in a more streamlined response that has greater potential to be effective than a laboratory-dependent strategy.
Laboratory-dependent confounding factors include differences in sample processing and data analyses, making comparability of data difficult.
Indeed, our results suggested that diversity profile-based analyses were very sensitive to laboratory-dependent experimental workflows (Additional files 1, 8 and 10).
Moreover, yields obtained with the protocols proposed by Epicentre and Arcturus appeared to be laboratory-dependent and non-reproducible in our hands (twofold changes in the amounts of amplified cDNA).
Note that the results obtained, before normalisation, with RNA amplified according to the Ambion MessageAmp™ protocol highlight the discrepancies in signal distribution that appear to be batch- or laboratory-dependent.
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