Until now, these laser exposures have been performed using a diode-pumped solid-state laser (DPSSL) devices, which are expensive and require labor-intensive maintenance and special training.
Despite the expression profile and the phenotypic resemblance, murine models also present limitations such as their relatively long development time and expensive and labor-intensive maintenance, laborious genome editing and, specifically for PXE, a relatively slow onset of the disease [ 65].
Such kind of networks are presumed to work in an unattended fashion and it is often difficult or labor intensive to provide any maintenance to the sensors.
While the reactively breakdown maintenance and blindly preventive maintenance do sometimes reduce equipment failures, they are more labor intensive, do not eliminate catastrophic failures and cause unnecessary maintenance.
Consequently, knowledge engineering for a new domain and knowledge maintenance for a fielded system are labor intensive and expensive.
As C. elegans, liquid DR methods are generally labor intensive, we developed a protocol that requires relatively low maintenance (Fig. 1A).
The decision to create multiple external mappings to EFO classes clearly presents additional overhead to both the initial set of mappings and the subsequent maintenance of these mappings, as both are labor intensive if performed manually.
While short hair can be cooler, maintenance on short hair can be more labor intensive than long hair.
PCR-based molecular screening methods are a universal option and have been demonstrated with CRISPR/Cas9-mediated NHEJ, but the associated generation and maintenance of candidate fly stocks is time and labor intensive (Yu et al. 2013).
However, because M. hapla is an obligate parasite, generation and maintenance of the F2 lines as living cultures is labor intensive and time consuming.
"But it is labor intensive.
