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Based on our observations, if these candidate labels are valid surrogates for the CSC-phenotype, then we cannot be confident that this is a "rare" population.
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Moreover, if the candidate CD44 and ALDH-labels were valid surrogate markers for CSC, then CSC seemed to reside in discrete protected microdomains (niches) in the MPE-tumor clusters.
It is instructive to point out that the metrics as defined in (30) and (34) are valid for single label systems; for multilabel systems, a set of more complicated metrics should be used as given in [ 114].
There are valid criticisms.
These concerns are valid.
These are valid criticisms.
Both are valid".
Both views are valid.
Both reasons are valid.
These suspicions are valid".
All are valid explanations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com