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This could be explained by earlier tracing studies that characterize the innervation of the dura mater where the application of the labelling substances on a caudomedial region of the dura mater, labelled neurons appeared bilaterally [28].
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Targeted assays can be highly sensitive and specific and reproducibly quantitative, especially when heavy isotopes are used to label substances and instrumental methods are narrowly focused.
However, pigments of tattoo ink can be transported to regional lymph nodes and potentially clog lymphatic pathways that might also be used by sentinel labeling substances.
The need to better protect consumers and products has stimulated interest in designing new labeling substances that offer the desired properties.
The work also demonstrates the reliability of an imaging technique using differential X-ray transmission radiography for the mapping of the consolidation action without requiring the use of labeling substances.
In other words, the concrete accidental terms label substances by means of the accidental forms from which they draw their names, so that they name substances only qua bearers (subiecta) of a form.
Recently, the development of a novel bioluminescent in vivo imaging system (IVIS) allowed monitoring in real-time labeled substances or cells in experimental animals.
However, the therapeutic benefit is accompanied by significant economic investments, unresolved medicolegal debates about the use of off-label substances and overwhelming problems in large population management.
In non-targeted metabolomics, uniformly labeled substances in combination with their natural pendants are added to biological samples during cultivation and used as tracers to study their metabolic fate [ 4].
However, it has never been adopted as a standard prognostic marker because the experiment requires fresh tumor tissue and a complex and time consuming radioactive assay for in vivo administration of labeled substances.
One of the solutions is to seek a kind of sensitive and stable labeling substance.
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