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Although the set of proteins carrying differently labelled variations (germline "cancer" and germline "other diseases") is small (20 proteins, Table 1), a total amount of 358 germline "cancer" and 405 germline "other diseases" variations can be predicted with the SVM based method.
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The position and label variations between two replications did not significantly alter the topography between slides.
Abdomen integuments from other resistant strains of An. gambiae are being dissected to search for further supporting evidence for a role of these transcripts in conferring resistance prior to follow up functional analysis.> -wrap-foot> Splice variants, as predicted by VectorBase, are labelled with variations of -Rx.
What is more, they neither reflect noise in label uptake, nor spatial heterogeneity such as label concentrations differing between organs, nor temporal label variations.
On the other hand, the mean offer increased all the way to $4.67 in the third-party label variation, with 72% making 50 50 offers (1995: 1415 1416).
The PI labeling efficiency of each sperm sample was measured by a flurorescence spectrometry, the microarray results were then normalized against the labeling efficiencies to reduce the effect of labeling variation.
In this case, loss of some markers due to labeling variation can be disregarded since there are multiple probes that can be used to evaluate the presence or absence of the gene or locus.
The iTRAQ quantification values of these proteins were normalized separately using median correction, to account for internal label variation, before a fixed ' α' value (0.5 with this data) was added to all quantifications, to remove the effects of missing labels and noise in the data on the ratio-driven quantification used with iTRAQ.
As the database contains various kinds of variation such as inversions, we selected only variations labelled as copyNumber.
For validating predictors, we also collected a second dataset of 3392 variations labelled "Somatic cancer" from UniProtKB present in 1983 proteins not included in the training set.
Noticeably with this last implementation it is possible to assign classifications to variations labelled differently in the same protein sequence (endowed with the same GO-scores).
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Justyna Jupowicz-Kozak
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