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Exceeding the labelled dosing in the time frame of one year after the index event in the TNF inhibitor naive patients occurred in 7.3% of adalimumab, 1.4% of etanercept and 17.2% of infliximab treated patients.
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The number of other (non-UK labelled) doses we have around Europe, which could be brought in (regulatory issues notwithstanding).
For efficacy assessments, labelled doses for OA treatment were used for the base case while labelled doses for RA treatment were also included in the sensitivity analysis.
Therefore, observed improvements in secondary endpoints such as 6MWD and NT-proBNP likely reflect compliance with the labeled dosing frequency rather than specific differences between the molecules.
Morphine cartridges that contain up to twice the labeled dose.
Current evidence shows that these agents are available systemically and have the capability of negatively affecting growth when administered to children at labeled doses.
"Hismanal is associated with risks of death due to irregular heart rhythms when taken with certain other drugs and when used at higher than the recommended labeled dose," the F.D.A. statement said.
A Multicenter, phase I open-label dose escalation study of ABBV-085 an antibody drug conjugated in subjects with advanced solid tumors.
Administration of higher than labeled doses of selective serotonin reuptake inhibitors may be a treatment option for certain OCD patients who fail to respond to standard acute treatment.
The quantity of labeled CO2 exhaled was expressed as percent labeled dose exhaled per hour (Schneider et al. 1978).
Despite being clinically stable on study entry, 38% of patients reported iloprost usage below the labeled dose.
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CEO of Professional Science Editing for Scientists @ prosciediting.com