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A gene is labeled as significant if its score surpasses a threshold.
In the GWAS literature, single nucleotide polymorphisms (SNPs) that reach association P-values <5 × 10−8 are generally labeled as significant genome-wide.
An original t-sum was labeled as significant if it exceeded the 95th percentile of the distribution of permuted t-sums for a given SD threshold.
A peak was labeled as significant if the corrected P-value was less than 0.01, the enrichment over input greater than 5 fold and the background corrected amount of reads contributing to a peak was more than 15.
We selected genes that fit the above criteria to discover potential personalized drivers: genes that labeled as significant from the maximally-selected rank statistics and genes that ranked higher in specific patients according to the Chauvenet's criterion.
A general summary is presented with the number of genes and metabolites of the selected species present in the current KEGG database version, the number of features matched by the input files and how many of those were labeled as significant.
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QTL with chromosome-wide significance (P < 0.05) were described as suggestive QTL, whereas QTL exceeding the P < 0.01 chromosome-wide levels and P < 0.05 experiment-wide levels were labelled as significant and highly significant QTL, respectively.
a significant and unique sub-map alignment; an alignment labeled as non-significant and/or non-unique (which will be considered as a false alignment); or no feasible alignments found.
Each glocal alignment sub-problem will then return either: (i) a significant and unique sub-map alignment; (ii) an alignment labeled as non-significant and/or non-unique (which will be considered as a false alignment); or (iii) no feasible alignments found.
If we had used only the morning sample, we would not have included and labeled as microalbuminuric a significant number of patients (18).
Further analysis using two-way ANOVA again demonstrated some changes between the control and docetaxel treated cells (Additional file 2: Table S2), with one annotated metabolite (labeled as ethanolamine) showing significant differences in the group category (Table 1).
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