Exact(15)
Both, tolerability and efficacy results in this setting compare well to published data of controlled and open label trials conducted in specialized academic institutions [12, 13, 23, 24].
First, many of the trials were open label trials.
In our review, about a third of the trials were open label trials.
Finally, two small open label trials of VPA in human subjects have reported modest strength or functional benefit in a subset of those patients [30], [31].
However, two were open label trials (Walsh 1999; Walsh 2004a).
Because of the difference in methodological quality between double blind studies and open label trials, a sensitivity analysis was carried out excluding open label trials.
Similar(45)
Open-label trials confirmed this trend [51, 57 60].
We included randomized controlled trials (RCT), open-label trials and retrospective studies.
The finding conflicts with the outcomes of previous case series and open-label trials.
The existing studies all deal with TN associated with multiple sclerosis and are small open-label trials.
Prophylactic drugs evaluated in placebo-controlled and open-label trials for migraine [50 71] have been summarized in Table 3.
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