To the contrary, several of the largest drug companies have paid billions to settle claims they illegally marketed antipsychotics to children and other off-label populations, such as the elderly.
In the second method, we labeled populations of excitatory neurons based on projection target by using herpes simplex virus 1 (HSV1), which is efficiently taken up by axons and transported retrogradely.
Consistent with this, the labeled populations of layer 2/3 neurons studied here had extensive projections to infragranular layers.
Because many of the labeled populations of neurons overlapped in space, it is difficult to discriminate between populations based on location alone.
Usually a ratio of intensities is calculated for each probe or gene, corresponding to two different labeled populations of reverse-transcribed mRNA.
Finally, we used the SRQ to avoid labelling populations with a psychiatric diagnosis, but using a self-reporting questionnaire has obvious limitations.
Our viral tracing method may allow trans-synaptic spread between dopamine neurons, which would make the trans-synaptically labeled populations appear more similar.
Because OA chondrocytes comprised distinctive annexin V and propidium iodide labeled populations, this indicated that chondrocyte death consisted of both apoptosis and necrosis.
(C ) Injection of hSyn-GFP-virus into the IO retrogradely labeled small, round NO neurons in the contralateral CN. (D ) Comparison of soma sizes among the three labeled populations.
Injections were made approximately 400 μm below the pia in the D2 column of left somatosensory barrel cortex and typically labeled populations of 200 to 400 layer 2/3 neurons.
