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Consequently, the high LA content of human milk (Kuipers, unpublished) and the ensuing postnatal surge in the infant LA status [ 35] suggest that the infant's RBC-AA decrease may also be a result of the high LA intake from breast milk.
The relationship between tumour growth, insulin status, blood lipids and adipose linoleic acid (LA, reflecting long-term LA intake) was studied in 19 Jewish women suffering from early and advanced stages (ES and AS) of ovarian and endometrial tumours.
This is the first published report to show an increase in mortality from cardiovascular disease and coronary heart disease, comparing this LA intervention to the control group, and demonstrating that the magnitude of increased n-6 LA intake was associated with higher risk of death.
It has been suggested that the need for n-3 LCPUFA is increased by high intake of LA, but observational studies have not been able to show that the effect of n-3 LCPUFA is modified by LA intake [ 29, 31, 32].
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The adverse effects of increasing n-6 LA from 6% of food energy to 15% in this cohort are not necessarily generalizable to lower LA intakes; therefore, some caution should be used when extrapolating results to other populations.
To the best of our knowledge, this is one of the first clinical reports to demonstrate an association between α-LA intake and depression (see Rudin (1981) for a case report).
α-Linolenic acid intake is known to have an influence on the fundamental structural and functional roles in the developing and mature nervous system (Bourre et al, 1993; Uauy et al, 1996), and an interaction between α-LA intake and neurotransmitters has been observed in animal experiments (Delion et al, 1996).
Another possibility is that the total ω-3 FA (including α-LA) intake may reflect the concentration of DHA and EPA in the body or brain, rather than the sum of EPA and DHA intake only, since α-LA is the main source of ω-3 FA in the diet and can be converted into DHA or EPA in humans.
In conclusion, we did not observe a significant relationship between total EPA and DHA intake and depression in newly diagnosed Japanese patients with lung cancer, but significant inverse relationships between α-LA intake or total ω-3 FA intake and depression were noted.
However, the association between α-LA intake or total ω-3 FA intake and depression should be further investigated.
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