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9 The present study focused on cT3 4 LA disease involving adjacent structures and compared the outcome of trimodality therapy with initial surgery in this population.
The prevalence of advanced disease was determined from the frequency of patients with metastatic or LA disease in 2010 regardless of evidence of NMSC in 2009.
Standard evaluations of diastolic function using pulsed-wave (PW) Doppler of mitral inflow and tissue Doppler imaging (TDI) supplemented with LA deformation studies can diagnose early LA disease processes, thereby guiding treatments to prevent the development or recurrence of AF.
Further the described recurrent nature of the LA disease was also seen in our study in 6 out of 16 patients with definite LA and 3 out of 5 patients with probable LA [ 14].
Cetuximab is an EGFR-targeting monoclonal antibody and is the only targeted treatment approved in the US and Europe for the treatment of HNSCC in combination with radiotherapy for LA disease and in combination with platinum-based chemotherapy for R/M disease [ 23, 24].
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"La, la, la, la.
N2 or N3 (N2–3) disease and T3 or T4 (T3–4) disease are considered locally advanced (LA) diseases.
Apart from the desire to look young, other indications include the correction of disabling volumetric soft tissue loss in HIV-associated facial lipoatrophy (HIV-LA), Romberg disease, and post-surgical and post-traumatic facial disfiguring [3, 4, 5].
We have used induction chemotherapy or CRT followed by surgery for the treatment of N2 3 LA-NSCLC disease since 1995.
From Lae, the disease initially spread to neighbouring Madang province, most likely over land by road, with two significant space time clusters appearing to the west of the original cluster in late September 2009 including Madang town, the capital of Madang province.
More data are required with respect to the natural history of LA remodeling in disease, the degree of LA modifiability with therapy, and whether regression of LA size translates into improved cardiovascular outcomes.
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