Sentence examples for la binding from inspiring English sources
Finally, intrinsic and extrinsic fluorimetry was used for examining the HMP protective role at the LA binding site.
Very recently, another RNA binding protein, HuR was shown to interact with 3′-UTR of HCV genome, compete with PTB but facilitate La binding to the 3′-UTR (Shwetha et al., 2015).
We also use AIMS to show that LA binding is reversible in intact cells, indicating that HNF4α could be a viable drug target.
To determine the specificity of LA binding, we asked whether LA, or other fatty acids, were bound to HNF4α proteins containing mutations in the LBP.
Although we could force this increase in LA binding, we did not observe an increase in binding of a related fatty acid (palmitoleic acid, PLA, C16:1) provided under similar conditions (Figure 1C, bottom).
To explore this possibility, we examined the transcriptional activity of the ΔN derivatives of the two non-LA binding HNF4α mutants (ΔN-V255M and ΔN-R226M) identified in Figure 1B.
Epidermal growth factor (EGF) receptor (EGFR) modulates mitosis and apoptosis through signaling by its high-affinity (HA) and low-affinity (LA) EGF-binding states.
Among the host factors controlling HCV replication or translation in trans, several candidates are involved in mediating both of these processes, including human La protein, poly rC -binding poly rC -binding) and mice minute virus NS1-associated protein 1 (NSAP1) (Ali et al., 2000; Ito and Lai, 1997; Chang and Luo, 2006; Spangberg and Schwartz, 1999; Park et al., 2011).
The O1s spectrum was fitted with three peaks (indicated by dashed line) after the application of a Smart background for samples A, B, and C. The dotted lines indicate the binding energy of La-O-La, La-Si-O, and La-OH peaks with the increasing binding energy [22-24] [22-24]
The dotted lines indicate the binding energy of La-O-La peak, La-Si-O peak, and La-OH peak with the increasing binding energy [20,22,24].
