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In addition to fitting the true PDF better, the results in this manuscript demonstrate that L values from the bivariate Gaussian model enable more accurate decoding than the standard circularly symmetric Gaussian.
The combination of the L values from TP1 and TP5 improved single-input classification performance (AUC = 0.84).
Using the L values from these pathways and models based on the KStar classifier, a maximum AUC (area under the receiver operating characteristic curve) value of 0.80 was obtained.
We also plotted these two values per sites with the Δpsln L values from the comparative netrin-4-netrin-1 and sFRP-1/2/5-sFRP-3/4 monophyly polyphyly analyses described above.
To exclude that the polyphyly of netrins and sFRPs is due to few sites with very high Δpsln L values, we progressively removed sites with the highest and lowest Δpsln L values from the top 5% to 25%10%50%50% removed sites in total) and performed ML analyses on these reduced datasets.
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where (widehat w^{hdr}_{s}), (widehat w^{hdr}_{L}), and (widehat w^{hdr}_{lumi}) represent the normalized HDR weight values for interpolated short exposed W ((widehat W^{up})), interpolated long exposed W ((widehat W_{L})), and luminance (L) value from RGB values, respectively.
The null hypothesis for gene interaction [ 36] was defined by a neutrality function consisting of the median L value from replicate cultures of the Yor1-ΔF single mutant across increasing oligomycin concentration, to account for the drug effect.
The smoothed L values for the BMI varied from −2.22 to −1.34.
This motivated us to investigate possible integrated classification strategies, which combined input features derived from our pathway-based VD+ model (L values) and from the GSEA method (highly differentially expressed genes).
The agreement between the L values estimated from the proposed correlation and experimental values is satisfactory with a standard deviation (s.d). of 0.119.
We revisited our previous studies on P-glycoprotein-membrane systems36 and observed that while A L values shifts from 0.636 nm2 (pure POPC) to 0.593 nm2 (20% CHOL POPC, −7%), in P-gp/bilayer systems comprising cholesterol (system built from the refined model but not included in ref15) the A L is 0.612 nm2 (3% increase).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com