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Thus, despite this significant advance our knowledge of the native conformation of a Kv channel in a membrane remains incomplete.
Additional recent findings suggest that Kv channel accessory subunits can respond to changes in intracellular Ca2+ or metabolism and thereby integrate signaling pathways to regulate Kv channel expression and properties.
With the increasing association of altered Kv channel functioning with neurological disorders, the potential impact of these efforts is clear.
Recent studies suggest that Kv channel accessory subunits subserve multiple roles in the generation of native neuronal Kv channels.
TEA acted as an unspecific Kv channel blocker in hNPCs.
TEA acted as a non-specific Kv channel blocker in hNPCs.
However, expression of Kv channel mRNA and electrophysiological or pharmacological Kv properties are quite distinct [25].
Thus, Kv channel expression seems to be not only region, but also species specific.
It is also recognized that Kv2.1 is not the only Kv channel of importance [2].
The expression of several Kv channel transcripts was quantified by real-time PCR analysis (Fig. 3B).
This effect was dependent on voltage-gated K+ (Kv) channel activity.
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