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Alternate splicing in exon 9 of WT1 and EWS/WT1 generates an insertion of three amino acids lysine, threonine and serine (KTS) between zinc fingers 3 and 4, producing + KTS and –KTS isoforms [ 5].
The TC intensity was divided into 5 stages on the basis of the intensity of the MSWS: tropical depression (TD; MSWS < 34 kts), tropical storm (TS; 34 kts ≤ MSWS ≤ 47 kts), severe tropical storm (STS; 48 kts ≤ MSWS ≤ 63 kts), typhoon (TY; MSWS ≥ 64 kts), and extratropical cyclone (EC).
110 kts at 850mb screaming into Long Island tonight.
In the medaka, an additional splice variant of Wt1, wt1a_dE4, with differences in exon 4 is present in both +KTS and –KTS isoforms [34].
KTS designed study and wrote the paper.
KTS participated to data analysis and interpretation.
Wild type MEFs expressing either eGFP, EWS/WT1-KTS or EWS/WT1 + KTS were treated with 10 Gy gamma irradiation.
Previous studies have indicated that the binding specificities of the ZF - KTS and ZF + KTS isoforms differ.
Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/WT1-KTS and EWS/WT1 + KTS.
Using the tetracycline repressible lentiviral expression vector we consistently observed higher levels of expression of EWS/WT1 + KTS compared to EWS/WT1-KTS.
Regardless, for all reporters tested, it appears that ZF - KTS is more potent at blocking transcription than the ZF + KTS isoform.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com