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Overall, our results are consistent with prior research showing P-gp at the BBB plays a dominant role in regulating the brain disposition of risperidone and 9-hydroxy risperidone, with the brain/plasma concentration ratios being markedly elevated in P-gp KO compared with WT mice (Boulton et al, 2002; Brzozowska et al, 2016; Doran et al, 2005; Wang et al, 2004).
To extract differentially expressed genes in KO compared with WT, Venn diagrams with 1.5-fold change in the three pairs comparisons was used as the filtering method.
Slc7a1 mRNA level was about 50% higher in Cav-1 KO compared with WT cells.
Ischaemia reperfusion damage was significantly attenuated in the p50 KO, compared with WT mice.
Uptake of radio-labelled Put and Spd was about 20% higher in Cav-1 KO compared with WT cells.
The Slc43a1 mRNA was up-regulated 2-3 tines in Cav-1 KO compared with WT cells.
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Serial echocardiographic measurements showed severe reduction in contractile performance in PI3K-gamma-KO compared with TgPIK mice.
In keeping with this, we observed decreased apoptosis of macrophages infected with OppD-KO compared with the wild type.
There was marked reduction of apoptosis of macrophages infected with OppD-KO compared with the wild type and restoration of the apoptosis-inducing ability in the complemented strain.
Most of the parameters measured by blood chemistry were not significantly different in the Wwox KOs compared with wild-type and heterozygotes (Table 3).
Parallel experiments with golli-KO compared with control OPCs showed no increase in caspase labelling.
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CEO of Professional Science Editing for Scientists @ prosciediting.com