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Maternal pre-pregnancy overweight is known to program offspring for adverse health outcomes later in life.
Usually, these studies are restricted to glucocorticoid overexposure (i.e. dexamethasone, or due to maternal stress) during gestation and intrauterine growth retardation, both known to program adult onset disorders such as cardiovascular diseases (hypertension), and metabolic (i.e. hyperglycemia, hyperinsulinemia), endocrine and behavioral disorders [35], [36].
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Each gene was known to impede programmed cell death.
Phagocytic cells interacting with other pathogens are known to undergo programmed cell death (PCD) to control the spread of the infectious agent [31].
Most of the prenatal challenges known to have programming effects have been associated with high levels of GCs in utero.
For example, β-Gal-Yariv treatment is known to promote programmed plant cell death, while overexpressing AGPs results in tomato plants with enhanced lifespans [ 67].
The bcl-2 gene encodes for a mitochondrial membrane proto-oncoprotein, the expression of which is known to suppress programmed cell death (apoptosis).
Thus, several pathways with the potential to regulate inflammation are known to be susceptible to programming influences.
A mass deportation program known to ensnare traffic violators and others for minor misdemeanors makes us more secure?
At present it is not known to what extent this program was successful.
Realizing outcomes Consider the full range of available strategies known to contribute to the program objectives.
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