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However, although there are now over 20 PMG genes known (Supplementary Material, Table S1), many cases remain unexplained.
RARα (RARα1-4), RARβ (RARβ1-2-5), and RARγ (RARγ1-5) splicing variants are known (Supplementary Fig S4).
Two KCC2 RNA splice variants with different N-termini are known (Supplementary Figure 1A), but neuroprotective effects were demonstrated for KCC2b only.
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We also identified truncating (and likely disease-causing) mutations in two affected samples in which previously only one mutation was known (see Supplementary Figure S5 online and Supplementary Table S5 online), as well as 9 carriers in the set of 139 previously uncharacterized HapMap, 1000 Genomes Project, and Human Diversity Panel samples (see Supplementary Table S5 online).
Although it is anecdotally known that supplementary material contains 'all of the information', and some researchers have speculated about the role of supplementary material (Schenck et al. Extraction of genetic mutations associated with cancer from public literature. J Health Med Inform 2012; S2 2 ., our analysis substantiates the significant extent to which this material is critical.
Tier two capital is also known as supplementary capital.
Academics and specialists have long been aware of flaws in the FBI numbers, which are based on voluntary submissions by local law enforcement agencies of paperwork known as supplementary homicide reports.
The Monte Carlo simulation had an appropriate type 1 error rate when the model learning parameter was known (see Supplementary Material, S1.1), but this was inflated, in the more realistic case, when α was estimated from the data (e.g. Round-Box: 24% estimated Type 1 error rate for 5% significance, 95% confidence interval: 21.5% to 26.7%).
14 These substudies, known as Supplementary Analysis of Nominated Data (SAND), investigate aspects of the patient health not necessarily managed at the encounter (full methods reported elsewhere).
Although aimed at improving access, it is not known whether supplementary funding changed the time that patients spent on wait lists for CABG.
For example, since the activity of each sub-unit of the homotetramer phosphofructokinase is not known (see Supplementary Materials), the global activity is annotated for the whole enzyme.
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