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We ranked all known genes localized on the 10.8 Mbp region of chromosome 6 based upon predicted EREs, genes' differential expression in MG thymi (which are likely sites of autoimmunization), their known responsiveness to estrogen, and their annotated biological roles.
A panel of 15 proteins was selected for investigation based upon their known responsiveness to changes in axonal and synaptic vulnerability (see Introduction; Table 1) (29– 31).
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Since much of this research has been cross-sectional in nature, little is known about responsiveness of many of the HRQoL measures to clinical change and treatment effects.
A broad panel of xenografts with known treatment responsiveness, and well-defined molecular profiles, would provide an excellent adjunct to these models [ 4].
This is in good agreement with the known reduced responsiveness of HER2/neu-positive tumour cells to chemotherapy (other than with subsequent antibody therapy [ 14], during which analyses were not performed).
Knowing the responsiveness of NHL to radiation in the ASCT regimen is essential.
In addition, the measurement properties of the questionnaires, including internal consistency reliability, test-retest reliability, construct validity, known groups validity, responsiveness to change over time, and an estimation of what change is clinically meaningful should be evaluated.
MLTCs are also known to retain responsiveness to human chorionic gonadotropin (hCG) [6] [8].
Vitamin D is known to reduce responsiveness of healthy donor DCs to the stimulatory effects of Type I IFN.
It is, therefore, intriguing that the FHIT gene is known for its responsiveness to environmental factors, such as smoking [15] and radiation exposure [17], and mediates cell survival or apoptosis [9].
However, the ability of these questionnaires to discriminate viral infection in acute asthma from a non-infectious exacerbation is not known, and their responsiveness in acute asthma is also unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com