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As illustrated in Fig. 1, our sequencing effort performed on 94 individuals allowed us to detect 5/13 of these known modifications and also, to characterize four additional mutations leading to a different amino-acid sequence of the TLR1 protein.
Different from other known modifications, acetylation can neutralize the positive charge of the lysine.
One of the best known modifications is the Roux-Elmslie-Trillat technique.
The locations of predicted RNA modifications based on OMMs corresponded well with locations of known modifications reported in the literature.
Others utilized a transgenic mouse model with known modifications to the collagen type II gene that result in the development of a truncated collagen fiber.
Although the histone PTMs are conserved structures in all eukaryotes, we can not exclude a priori other modifications or new combinations of known modifications in fungi.
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A frequently encountered engineering problem is the prediction of the natural frequencies of a modified structure based on a truncated set of modes and frequencies of the unmodified structure (modal testing results), and on the known modification matrices.
Particular attention was given to the known modification sites observed in other species.
Potential PTM of histone H2A were apparent by screening the masses of the full-length H2A histone for known modification-specific mass increments.
The latter being the only known modification when the wobble rules were devised.
This site corresponds to the known modification site of N4-acetylcytidine (acC) [ 4].
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