Modularity and Extensibility: different functional blocks should be implemented in a modular fashion (with known interfaces to connect the different blocks), so that new functionalities are easily introduced by substituting one functional block with a new one.
HomPPI [ 20] derives linear combinations of BLAST statistics correlated to conservation score in known interfaces, allowing an estimation of conservation in unknown interfaces.
Second, structural data is missing for a large number of interactions so that although interactions are known, interfaces may not be.
The efficacy and accuracy of the current algorithm has been demonstrated using standard test cases involving reconstruction of known static interface shapes and dynamically evolving interfaces in prescribed flow situations.
It is generally known that interface modification by doping results in the enhancement of electron injection due to the reduction of the electron injection barrier [48 51].
However, the processes involved in this link between "language brain" and "social brain" are still poorly known: the interface between language and social cognition remains a mystery [2].
Therefore, when looking for possible implications for the structure of the presumed trimeric eIF2Bα/β/δ complex, the authors had to ignore the known dimerization interface (>1500 Å of buried surface area, light blue line in Figure S4A,B of the Supporting Information).
The stoichiometry of the two coat layers is 1 2 outer:inner in coated tubes, meaning that only half of the inner coat subunits are bound by the known Sec31 interface.
