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In the event of febrile illness (T >38°C), development of a cough, or progressive inflammation at the site of a known inoculation event, blood cultures (initially 2 sets from different venipuncture sites), sputum culture, throat swab, and urine culture (using selective bacterial culture medium such as Ashdown medium or B. cepacia agar [ 24 ]) should be performed, as well as a chest radiograph.
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The concept has applications for dealing with political propaganda and is known as inoculation theory.
The process by which the pathogen is introduced into the body is known as inoculation, and the organism it affects is known as a biological host.
How would I know that inoculation had done anything?
The earliest procedure used to prevent smallpox was inoculation (known as variolation after the introduction of smallpox vaccine to avoid possible confusion).
The resulting scar at the site of inoculation, known as the "take," has been historically accepted as the correlate of protection for smallpox.
It is known that the inoculation of PPR virus on to BK cells can produce a similar result, and PPR has been misdiagnosed as rinderpest on several previous occasions.
For instance, one of the most vocal early American advocates of variolation, as the early 18th-century practice of inoculation was known, was Cotton Mather, the Bible-thumping Massachusetts Puritan and supporter of the Salem witch trials.
We used inoculation methods known to produce infection in larvae of these species [22].
The trials reported in these studies made use of natural field infection rather than artificial inoculation with known strains.
It was chosen for this work because the fate of the cells after i.v. inoculation is known from the literature [ 34– 36] and prior work in our laboratory.
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