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A high proportion of the recurrently mutated loci correspond to known drivers of human malignancies3,4.
Many already known drivers of change, e.g. new innovations in technologies, have an impact on these socio-technical systems.
Screening of two BCL2 transgenic models confirmed known drivers of human non-Hodgkin lymphoma, and implicates novel candidates including modifiers of immunosurveillance and MHC loci.
Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs.
Burdened by an unreliable Mercedes, he is in 15th place in the standings, just ahead of a bunch of barely known drivers who are sometimes referred to as mobile chicanes for the faster drivers.
We selected seven known drivers: (1) GDP, (2) population density, (3) distance to main rivers, (4) distance to roads, (5) distance to railways, (6) distance to ports, and (7) distance to airports.
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This list includes many known driver genes (e.g., MITF), which CONEXIC correctly identified and paired with their known targets.
The analysis found 18 new driver genes (labeled red), never before implicated in glioblastoma and correctly identified the 15 previously known driver genes (labeled blue).
Although DNMT3A is a known driver gene in AML37, the significance of this finding in neuroblastoma is uncertain at present.
A study has found 18 new genes that drive an aggressive form of brain cancer, doubling the number of known driver genes of glioblastoma.
However, between 40% and 60% of cases arise from the accumulation of what appear to be random mutations outside of known driver genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com