Sentence examples for known driver from inspiring English sources

Since energy metabolism in cancer cells is regulated in part by hypoxia [43], and hypoxia is a well known driver of tumorigenesis, we investigated levels of hypoxia between the two groups.

Except for FOXO1 and CIITA, known driver mutations did not correlate with EFS24.

In BRCA, known driver CNVs include amplifications in CCND1, MYC, GATA3, and EGFR and deletions in MAF.

Furthermore, suboptimal dosing is a well known driver for the development of antibiotic resistance during antibiotic therapy [ 8].

Mutations in known driver genes found in the primary tumour and metastasis were also detected in corresponding CTC.

Pegasus top driver scores (PDS > 0.8) predicts 46% of known driver gene fusions in GBM data from TCGA cohort.

The rare driver distribution of Basal-like cancer is also different from the frequency distribution of known driver genes.

These studies estimated that the nsBMR from the set of genes remaining after the most highly mutated previously known driver genes were removed from the dataset.

In addition to known driver genes with CNVs, we also identified novel driver CNVs not in CGC (Additional file 1: Figure S7).

First, ST-HSCs exist in a G0 state, yet they express a known driver of G1 progression (CDK6) while lacking the cognate partners (CyclinD1 and CyclinD3) of CDK6.

In GBM, known CNV drivers (based on CGC) include the amplification of some well-known driver genes such as EGFR, PDGFRA, and MYC and the deletions of MLLT3 and ANK3.