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This could be explained by a known developmental delay caused by chronic mTOR inhibition during development50.
Epidemiological evidence is very limited, but severe irreversible effects have been observed in humans following in utero exposures to a few known developmental neurotoxicants.
Some exploit known developmental programs in order to either grow whole donor kidneys within living recipients or engineer transplantable kidney tissue in vitro starting with embryonic kidney cells.
In this chapter, we review strategies for directing medium spiny neuron differentiation, based on known developmental principles, and we discuss the remaining hurdles on the road to engineering such cells for therapeutic application in Huntington's disease.
In this study, parent-reported social skills and problem behaviors among students with typical development (n = 79) were compared with those of age- and gender-matched students with a known developmental disability (n = 79) using the SSIS-RS-C.
This study evaluated the neurotoxicity of tris (1,3-dichloro-2-propyl) phosphate (TDCPP) compared to the organophosphate pesticide, chlorpyrifos (CPF), a known developmental neurotoxicant.
Our results reinforce the potential for in vitro models to aid in the rapid and cost-effective screening for comparative effects among different chemicals in the same class and in relation to known developmental neurotoxicants.
Mercury (thimerosal) is another toxic heavy metal, a known developmental neurotoxin, that is used in some mascaras and eye drops.
The time points chosen here were coinciding with known developmental events [12].
Taken together with the observed trends in biochemical components, our results suggest that the self-assembling process embodies many of the known developmental characteristics for articular cartilage.
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Although cereblon's role in the cell is still unknown, Handa and his colleagues think that it might be a link between the drug and better-known developmental genes that direct limb development.
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