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Our growing knowledge of transporter biology will greatly accelerate the discovery of novel drug targets and development of first-in-class therapies.
To our knowledge this transporter has not been previously described in the context of grape ripening.
Yet, such methods hardly determine the specificity of transporters; knowledge of transported metabolites is therefore often completed using direct information on the microorganism's physiology and the metabolites it was shown to utilize in growth experiments.
To our knowledge these transporters have not been previously described in the context of grape ripening.
To our knowledge, sulfate transporters have not been characterized in D. melanogaster; the temporal and spatial regulation of these two genes, however, suggests that they might play a role in GAG synthesis early during embryogenesis.
Our knowledge about specific transporter systems, as well as efflux pumps and metabolizing enzymes in the lungs is currently still in its infancy, although there is evidence of transporters in context of pulmonary drug absorption and delivery (Patton et al. 2010).
To date, knowledge of the transporter proteins in the tonoplast is surprisingly scarce.
We have evaluated the performance of TIP on several randomly selected organisms versus TransportDB, a high-quality standard for transporter knowledge.
In these circumstances, quantitative mathematical modeling is an essential tool, both to integrate detailed knowledge of individual transporters and to extract the properties emergent from their interactions.
MD contributed expert knowledge on ABC transporters and phylogenetic analysis, took part in the revision of this article.
However, knowledge of ABC transporters as cancer stem cell markers can be exploited to determine the plausible prognosis for various types of cancers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com