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Some particularists are prepared to bite this bullet, steadfastly maintaining that such "default valences" are mere summaries of moral knowledge restricted to specific past acts of moral decision making, wherein all the factors "added up" in a certain way; but others lament the loss of explanatory power resulting from such a dismissal of generalizations.
The repertoire of luciferases used so far as reporters in malaria parasites is to our knowledge restricted to the Renilla and the P. pyralis enzymes, with only the latter luciferase being used in HTS and live imaging applications.
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That is, Kant's constructivist foundation for scientific knowledge restricts science to the realm of appearances and implies that a priori knowledge of things in themselves that transcend possible human experience — or transcendent metaphysics — is impossible.
It is conceivable that our process experts, because of their adequate but relatively limited relevant knowledge, restrict themselves to the core material.
Recent molecular studies have demonstrated surprising intertumoral molecular heterogeneity that was unexpected, creating even more challenges than we thought previously. 2 In gastric cancer, our limited knowledge restricts us even further, but it may be time to face that challenge.
If, by stipulation, knowledge is ultimately knowledge "by acquaintance," then knowledge is restricted to knowledge of individual objects.
The second is to broaden the concept of knowledge by not restricting knowledge to knowledge by acquaintance but to allow for other forms of knowledge as well.
Since all theories accept this knowledge-truth connection, reliabilism as a distinctive approach to knowledge is restricted to theories that involve truth-promoting factors above and beyond the truth of the target proposition.
Jobs requiring specialized technical knowledge were restricted to whites.
Those sages who practice wuwei live out of their original nature before it was tampered with by knowledge and restricted by morality; they have reverted to infancy (that is, the undiminished vitality of the newborn state); they have "returned to the state of the Uncarved Block (pu)." Pu is uncut and unpainted wood, simplicity.
Hence, its "knowledge" is restricted to what it can prove.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com