Estimating an optimal set of parameters by optimization algorithms requires knowledge of the sensitivity of the process of interest to model parameters.
To resolve multiple mission goals and sensor requirements, detailed knowledge of the sensitivity of sensor performance to these aspects of mission design is required.
By combining current understanding of likelihood of the climate change hazard with knowledge of the sensitivity of a given catchment, it is possible to evaluate the fraction of climate model projections that would not be accommodated by specified safety margins.
However, the 95% credible interval around this estimate was very wide from 17.8% to 65.6%, reflecting the uncertainty in our knowledge of the sensitivity and specificity of TST.
In addition, the knowledge of the sensitivity of the reagent is mandatory.
Selection of an optimal cut-off point largely depends on the purpose of using the risk score and requires knowledge of the sensitivity, specificity, PPV, and NPV.
The increasing resistance of S. pneumoniae to penicillin (in more than 10% of isolates) has created a problem for therapy, which at present cannot be completely optimized and requires a knowledge of the sensitivity phenotype of the bacteria in question.
Selection of an optimal cut-off point largely depends on the purpose of utilizing the risk score and requires knowledge of the sensitivity and specificity of a risk score.
Both methods require knowledge of the sensitivity of the score function, where sensitivity is defined as the smallest upper bound of how much the function can vary when one record in the input database changes (see Definition 3).
These investigations are a first step of an ongoing overall evaluation of this new method, and without full knowledge of the sensitivity of the algorithms and their overall performance, which are investigated in a separate study to be published elsewhere, no definite conclusions should be drawn as to the suitability of this method for assessment of the recent infection rate in a population.
